UHRF1 is a sensor for DNA interstrand crosslinks
نویسندگان
چکیده
The human genome is guarded against mutations by several DNA repair pathways. Common for all pathways, is the initiating event of detecting the DNA damage. This initial event is followed by the coordinated recruitment of various other DNA repair proteins needed for the repair. For instance, the MSH2/MSH6 complex detects DNA mismatches, while the MRN or KU70/KU80 complexes detect double strand breaks. We have recently identified the UHRF1 protein as a sensor for DNA interstrand crosslinks (ICLs) [1].
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